Asymmetric total synthesis of epolactaene. Part 2: Introduction of the side chain and synthesis of (+)-epolactaene and its enantiomer

Article abstract of DOI:10.1016/S0040-4020(99)00368-3

A total synthesis of the novel neuritogenic agent (+)-epolactaene ((+)- 1) has been achieved via a convergent route that utilized epoxyamide 8, C7- C11 fragment 7, and C1-C6 Wittig reagent derived from phosphonium salt 19 followed by cyclization to form t