REACTION OF SPIRO WITH GRIGNARD REAGENTS IN THE PRESENCE OF CUPROUS CHLORIDE

DOI: 10.1246/cl.1985.427

Source and publish data:

Chemistry Letters p. 427 - 428 (1985)

Update date:2022-08-03

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Authors:

Rodriguez, Gonzalo

Benito, Yolanda

Temprano, Fernando

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Article abstract of DOI:10.1246/cl.1985.427

Attack of MeMgI and PhMgBr in toluene on spiro (1) in the presence of Cu2Cl2 gives 2'-substituted spiro in quantitative yields.Also, attack of PhCH2CH2MgBr on 1 in the presence of Cu2Cl2 afforded 2'-phenethyl, 2'-H and 2'-benzyl (or 2'-p-xylyl) derivatives in toluene (or p-xylene) as solvent.

Full text of DOI:10.1246/cl.1985.427

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