Synthesis of a ketorolac model via aromatic carbenoid insertion

DOI: 10.1002/hlca.19980810212

Source and publish data:

Helvetica Chimica Acta p. 317 - 323 (1998)

Update date:2022-08-05

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Authors:

Mueller, Paul

Polleux, Philippe

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Article abstract of DOI:10.1002/hlca.19980810212

The decomposition of diazo ester 2b with chiral Rh(II) catalysts proceeded via intramolecular aromatic carbenoid insertion to the racemic pyrrole derivative 5b in 72% yield. In contrast, the benzoylated precursor 16 afforded no ketorolac 1b when exposed t

Full text of DOI:10.1002/hlca.19980810212

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