Synthesis and Transformations of Methyl (E)-2-(Acetylamino)-3-cyanoprop-2-enoate und Methyl (E)-2-(Benzoylamino)-3-cyanoprop-2-enoate, Versatile Reagents for the Preparation of Polyfunctional Heterocyclic Systems

DOI: 10.1002/hlca.19980810205

Source and publish data:

Helvetica Chimica Acta p. 231 - 235 (1998)

Update date:2022-07-30

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Authors:

Pizzioli, Lucija

Ornik, Brina

Svete, Jurij

Stanovnik, Branko

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Article abstract of DOI:10.1002/hlca.19980810205

Methyl (E)-2-(acetylamino)-3-cyanoprop-2-enoate (2a) and its 2-benzoyl analog 2b were prepared from the corresponding methyl (Z)-2-(acylamino)-3-(dimethylamino)propenoates 1. Multifunctional compounds 2 are versatile synthons for preparation of polysubstituted heterocyclic systems such as pyrroles 4, pyrimidines 5 and 6, pyridazines 7, pyrazoles 8, 9, and 11, and isoxazoles 10.

Full text of DOI:10.1002/hlca.19980810205

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