Helvetica Chimica Acta p. 231 - 235 (1998)
Update date:2022-07-30
Topics:
Pizzioli, Lucija
Ornik, Brina
Svete, Jurij
Stanovnik, Branko
Methyl (E)-2-(acetylamino)-3-cyanoprop-2-enoate (2a) and its 2-benzoyl analog 2b were prepared from the corresponding methyl (Z)-2-(acylamino)-3-(dimethylamino)propenoates 1. Multifunctional compounds 2 are versatile synthons for preparation of polysubstituted heterocyclic systems such as pyrroles 4, pyrimidines 5 and 6, pyridazines 7, pyrazoles 8, 9, and 11, and isoxazoles 10.
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Doi:10.1002/anie.202103465
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(1994)Doi:10.1002/hlca.19850680517
(1985)Doi:10.1080/00397910500522157
(2006)Doi:10.1021/jm980405i
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