An efficient synthesis of the side chain intermediate of BO-2502A, a new 1β-methyl carbapenem, via diastereoselective lactamization as a key step

DOI: 10.1016/S0040-4020(98)00007-6

Source and publish data:

Tetrahedron p. 2423 - 2432 (1998)

Update date:2022-08-03

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Authors:

Ohtake, Norikazu

Imai, Yasuyuki

Ushijima, Ryosuke

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Article abstract of DOI:10.1016/S0040-4020(98)00007-6

The BO-2502A side chain intermediate 3 was prepared via the diastereoselective lactamization of the in situ prepared amino diacid anhydride 14 as a key step. The diastereoselectivity of this step was found to be 53:1 (96% de).

Full text of DOI:10.1016/S0040-4020(98)00007-6

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