A short asymmetric synthesis of 2,5-disubstituted pyrrolidines

DOI: 10.1016/S0040-4039(98)00134-8

Source and publish data:

Tetrahedron Letters p. 1697 - 1700 (1998)

Update date:2022-08-03

Topics:

Authors:

Katritzky, Alan R.

Cui, Xi-Lin

Yang, Baozhen

Steel, Peter J.

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Article abstract of DOI:10.1016/S0040-4039(98)00134-8

A novel approach to chiral 2,5-disubstituted pyrrolidines, starting from chiral 2-phenyl-glycimol, 1,5-dimethoxytetrahydrofuran, and benzotriazole, involves the diastereoselective substitution by Grignard reagents of a benzotriazolyl group in a crystalline intermediate obtained in high yield.

Full text of DOI:10.1016/S0040-4039(98)00134-8

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