A practical synthesis of (S)-oxybutynin

Article abstract of DOI:10.1016/S0040-4039(02)02135-4

(S)-Oxybutynin, an important drug acting as muscarinic receptor antagonist, was practically synthesized using catalytic enantioselective cyanosilylation of cyclohexyl phenyl ketone (6a) as a key step. Cyanohydrin 7a with 94% ee was obtained with 1 mol% of