Synthesis of protected, chiral α,α-disubstituted α-amino acids via a Beckmann rearrangement

Article abstract of DOI:10.1016/S0040-4039(98)00309-8

The synthesis of chiral, nonracemic, fully protected α,α- disubstituted α-amino acids via the Beckmann rearrangement of tosylated oximes 1 is described. The desired amino acids were obtained in good yields with excellent enantioselectivities in relatively few steps.