Enzymes in organic chemistry, 8.[1] Protease-catalyzed kinetic resolution of α-chloroacetoxyphosphonates in a biphasic system

Article abstract of DOI:10.1080/10426509808033735

Protease Chirazyme P-2 hydrolyses racemic α-chloroacetoxyphosphonates (±)-1 enantioselectively to furnish α-hydroxyphosphonates (R)-(-)-2 with ee's ranging from 31 to 97% at a conversion of 45% and unreacted esters (S)-(+)-1.

Full text of DOI:10.1080/10426509808033735

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Phosphorus, Sulfur, and Silicon
and the Related Elements
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ENZYMES IN ORGANIC
CHEMISTRY, 8.[11 PROTEASE-
CATALYZED KINETIC
RESOLUTION OF α-
CHLOROACETOXYPHOSPHONATES
IN A BIPHASIC SYSTEM
Friedrich Hammerschmidt a & Frank Wuggenig a
a Institut für Organische Chemie der Universität
Wien , Währingerstraβe 38, A-1090, Wien, Austria
Published online: 24 Sep 2006.
To cite this article: Friedrich Hammerschmidt & Frank Wuggenig (1998) ENZYMES
IN ORGANIC CHEMISTRY, 8.[11 PROTEASE-CATALYZED KINETIC RESOLUTION OF α-
CHLOROACETOXYPHOSPHONATES IN A BIPHASIC SYSTEM, Phosphorus, Sulfur, and
Silicon and the Related Elements, 141:1, 231-238, DOI: 10.1080/10426509808033735
To link to this article: http://dx.doi.org/10.1080/10426509808033735
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