Zolimidine analogues: The synthesis of imidazo[1,2-α]pyridine-based sulfilimines and sulfoximines

Article abstract of DOI:10.1055/s-0034-1380109

Zolimidine is a methylsulfonyl-substituted drug with an imidazo[1,2-α]pyridine core used for the treatment of peptic ulcer. Herein, we report the synthesis of unprecedented N-acetylsulfilimine and -sulfoximine- analogues under mild conditions. Deprotection of the N-acetylsulfoximine allows the preparation of the corresponding NH-sulfoximine.