Peptide inhibitors of N-succinyl diaminopimelic acid aminotransferase (DAP-AT): A novel class of antimicrobial compounds

Article abstract of DOI:10.1016/S0960-894X(98)00149-8

Dipeptide substrates of N-Succinyl Diaminopimelic Acid Aminotransferase (DAP-AT) were converted to hydrazines by treatment with hydrazine and cyanoborohydride. These compounds were tested in vitro as inhibitors of DAP- AT from E. coli and in vivo as antibiotics. The hydrazinodipeptides showed potent slow binding inhibition of DAP-AT as well as antimicrobial activity.