Synthesis of β-difluorine-containing amino acids

Article abstract of DOI:10.1016/S0960-894X(98)00168-1

A convenient strategy was developed to prepare several β-difluoroamino acids. As exemplified by the synthesis of 3,3-difluoro-L-homocysteine, 3,3- difluoro-L-homoserine and 3,3-difluoro-L-methionine, the reaction sequence all started from L-isoascorbic acid. This approach holds potential to be extended to make other β-difluorine-containing amino acids.