Bioorganic and Medicinal Chemistry Letters p. 1097 - 1100 (1998)
Update date:2022-08-05
Topics:
Li, Keqiang
Leriche, Caroline
Liu, Hung-Wen
A convenient strategy was developed to prepare several β-difluoroamino acids. As exemplified by the synthesis of 3,3-difluoro-L-homocysteine, 3,3- difluoro-L-homoserine and 3,3-difluoro-L-methionine, the reaction sequence all started from L-isoascorbic acid. This approach holds potential to be extended to make other β-difluorine-containing amino acids.
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