Bioorganic and Medicinal Chemistry Letters p. 2503 - 2508 (1999)
Update date:2022-09-26
Topics:
Cody, Wayne L.
Augelli-Szafran, Corinne E.
Berryman, Kent A.
Cai, Cuiman
Doherty, Annette M.
Edmunds, Jeremy J.
He, John X.
Narasimhan, Lakshmi S.
Jan, Penvose-Yi
Plummer, Janet S.
Rapundalo, Stephen T.
Rubin, J. Ronald
Van Huis, Chad A.
Leblond, Lorraine
Winocour, Peter D.
Siddiqui, M. Arshad
Potent and selective thrombin inhibitors have been prepared with a piperazinedione template and L-amino acids. Likewise, incorporation of D-amino acids led to potent inhibitors with a novel mode of binding. Herein, the structure activity relationships and structural aspects of these compounds will be described.
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