The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: Part 2

Article abstract of DOI:10.1016/S0960-894X(99)00419-9

Potent and selective thrombin inhibitors have been prepared with a piperazinedione template and L-amino acids. Likewise, incorporation of D-amino acids led to potent inhibitors with a novel mode of binding. Herein, the structure activity relationships and structural aspects of these compounds will be described.