Bioorganic and Medicinal Chemistry p. 1257 - 1265 (1997)
Update date:2022-08-05
Topics:
Posner, Gary H.
Ploypradith, Poonsakdi
Hapangama, Whitney
Wang, Dasong
Cumming, Jared N.
Dolan, Patrick
Kensler, Thomas W.
Klinedinst, Donna
Shapiro, Theresa A.
Zheng, Qun Yi
Murray, Christopher K.
Pilkington, Lynn G.
Jayasinghe, Lalith R.
Bray, Jeff F.
Daughenbaugh, Randy
A series of tetracyclic and tricyclic trioxane dimers has been prepared with ether and ester tethers of varying length and flexibility. Several of these trioxane dimers have been found to have potent and potentially therapeutically valuable antimalarial, antiproliferative, and antitumor activities in vitro.
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