Asymmetric synthesis of α,α-disubstituted α-amino acide derivatives using MABR promoted rearrangement

Article abstract of DOI:10.1016/S0040-4039(98)00576-0

An efficient route for the asymmetric synthesis of α,α-disubstituted α-amino acids derivatives (1, 2, and 3) starting from readily available epoxy silyl ethers (6) has been developed. High enantiomeric purity can be realized by the present method using a combination of MABR rearrangement of a chiral epoxide and Curtius rearrangement.