WA8242A1, A2 and B, novel secretary phospholipase A2 inhibitors produced by Streptomyces violaceusniger. III. Structure elucidation and total synthesis of WA8242B

DOI: 10.7164/antibiotics.51.655

Source and publish data:

Journal of Antibiotics p. 655 - 664 (1998)

Update date:2022-09-26

Topics:

Authors:

Yoshimura, Seiji

Otsuka, Takanao

Takase, Shigehiro

Okamoto, Masanori

Okada, Satoshi

Hemmi, Keiji

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Article abstract of DOI:10.7164/antibiotics.51.655

The structure of WA8242B, a potent novel inhibitor against phospholipase A₂, was fully characterized by spectroscopic methods and chemical degradation. The success of total synthesis of WA8242B confirmed the structure and allowed the pharmacological study of WA8242B. The structures of WA8242A₁ and A₂ were also described.

Full text of DOI:10.7164/antibiotics.51.655

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