WA8242A1, A2 and B, novel secretary phospholipase A2 inhibitors produced by Streptomyces violaceusniger. III. Structure elucidation and total synthesis of WA8242B

DOI: 10.7164/antibiotics.51.655

Source and publish data:

Journal of Antibiotics p. 655 - 664 (1998)

Update date:2022-09-26

Topics:

Authors:

Yoshimura, Seiji

Otsuka, Takanao

Takase, Shigehiro

Okamoto, Masanori

Okada, Satoshi

Hemmi, Keiji

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.7164/antibiotics.51.655

The structure of WA8242B, a potent novel inhibitor against phospholipase A₂, was fully characterized by spectroscopic methods and chemical degradation. The success of total synthesis of WA8242B confirmed the structure and allowed the pharmacological study of WA8242B. The structures of WA8242A₁ and A₂ were also described.

Full text of DOI:10.7164/antibiotics.51.655

Products guided by the article

Product name:(3S)-3-[(2S)-5-benzyloxycarbonyl-2-{(3S)-3-hydroxy-15-methylhexadecanoyl}aminopentanoyl]oxy-15-methylhexadecanamide

Cas No:213336-71-1

R&D Labs maybe for 213336-71-1

SPE Chemicals Co.,Ltd

Contact:

Address:ROOM 1715, No#345 Jin Xiang Road, Pudong District
SICHUAN ZHONGBANG NEW MATERIAL CO., LTD

website:http://www.zhongbangst.com

Contact:86-830-2585019

Address:sichuan,china
Nanjing Fubang Chemical Co.,Ltd

Contact:+86-25-83179199

Address:5F,Tianzheng international plaza,No399 Zhongyang Road ,Nanjing China
Synasia Inc

Contact:17316303296

Address:240 Amboy Ave
Yantai Derun Liquid Crystal Materials Co. Ltd.

website:http://www.ytderun.com

Contact:86-535-6300169

Address:ROOM 90, XIANGFU STREET, FUSHAN NEW-HIGH-TECH IDUSTRY ZONE, YANTAI

Relevant to this article

The dichloromethane induced fragmentation of ferrocenylmethyldimethylamine. Mechanistic aspects and crystallographic and electrochemical investigation of the (FcCH2)2NMe2(+) and FcCH2NMe2H(+) ions

Doi:10.1016/S0022-328X(98)00866-3
(1998)
Enantioselective synthesis of pyrano[2,3-: C] pyrrole via an organocatalytic [4 + 2] cyclization reaction of dioxopyrrolidines and azlactones

Doi:10.1039/c9ob00419j
(2019)
Synthesis and characterization of ruthenium complexes of 1,8-bis(diphenylphosphinomethyl)naphthalene (BDNA) and their catalytic hydrogenation reactions to α,β-unsaturated aldehydes

Doi:10.1016/S0022-328X(98)00889-4
(1998)
Contra-Thermodynamic, Photocatalytic E→Z Isomerization of Styrenyl Boron Species: Vectors to Facilitate Exploration of Two-Dimensional Chemical Space

Doi:10.1002/anie.201800286
(2018)
Doi:10.1039/jr9370000546
()
Intramolecular cyclizations of enynes using RuClH(CO)(PPh₃)₃

Doi:10.1021/jo981715b
(1998)

Article Doi