Tetrahedron Letters p. 4067 - 4070 (1998)
Update date:2022-08-05
Topics:
Kohgo, Satoru
Shinozuka, Kazuo
Ozaki, Hiroaki
Sawai, Hiroaki
A novel 2'-deoxyuridine derivative bearing a cyanomethoxycarbonylmethyl group at the C-5 position (1) was synthesized, and its use was examined as a convertible nucleoside for the versatile post-synthesis functionalization of oligodeoxyribonudeotides (ODNs). The ODNs containing reacted with primary monoamines such as heptylamine, histamine, and tyramine as well as di- and polyamines under mild conditions, giving the corresponding derivatized ODNs.
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Doi:10.1016/S0277-5387(97)00400-2
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(1997)Doi:10.1039/a800779i
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(1997)Doi:10.1016/S0040-4020(00)00316-1
(2000)