
Tetrahedron p. 311 - 314 (1984)
Update date:2022-08-02
Topics:
Beugelmans, Rene
Chastanet, Jacqueline
Roussi, Georges
The SRN1 reaction between o-halogeno-benzylamines and enolates derived from a series of ketones and aldehydes affords 1, 2 dihydro-isoquinolines from which are obtained (i) the isoquinoline derivatives, either spontaneously or by treatment on Pd-C and (ii) the 1, 2, 3, 4 tetrahydro-isoquinoline derivatives after sodium borohydride reduction.
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