A straightforward preparation of chiral 5-(aminomethyl)oxazole derivatives from α-amino esters and α-lithiated isocyanides

DOI: 10.1248/cpb.46.860

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 860 - 862 (1998)

Update date:2022-08-04

Topics:

Authors:

Ohba, Masashi

Kubo, Hiroyuki

Seto, Shigeki

Fujii, Tozo

Ishibashi, Hiroyuki

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Article abstract of DOI:10.1248/cpb.46.860

An efficient and general preparation of several chiral N-protected 5- (aminomethyl)oxazoles has been accomplished by treatment of N-protected α- amino esters with α-lithiated isocyanides, obtained by metalation of methyl and benzyl isocyanides with BuLi or of ethyl isocyanide with lithium diisopropylamide.

Full text of DOI:10.1248/cpb.46.860

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