Toward supramolecular ion channels formed by oligonucleotide analogs: Hydrophobic guanine dimers

Article abstract of DOI:10.1016/S0040-4039(98)00651-0

In this model study toward supramolecular channels formed by oligonucleotide analogs, we describe the synthesis of hydrophobic guanine dimers 1 - 4. We found that the solubility of guanine dimers 1 - 4 is significantly reduced compared to hydrophobic (iso)guanosine monomers and independent of the nature of substituents at the exocyclic amine. This indicates that the (deoxy)ribose is important to form soluble, ionophoric G- quartets.