Bioorganic and Medicinal Chemistry Letters p. 1201 - 1206 (1998)
Update date:2022-07-29
Topics:
Basten
Dreef-Tromp
De Wijs
Van Boeckel
The syntheses of several heparin-like glycoconjugates (i.e., 16a-f) containing identical AT III binding domains (ABD) and spacers but different thrombin binding domains (TBDs) are described. Biological activities of conjugates 16a-f indicate that the thrombin inhibitory activity is mainly determined by the charge density of the TBD moiety.
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