Intramolecular heck reaction: Synthesis of benzo[4,5]cyclohepta[b]indole derivatives

Article abstract of DOI:10.1016/S0040-4020(98)00412-8

An intramolecular Heck reaction was performed with palladium(II) acetate on iodoethylenic esters 6-7 to afford an ethylenic seven-membered system 8- 9. α-alkylation of 8 was investigated to afford the corresponding α-methyl compound 10. This new family of compounds 11-12 gave access to potential antiinflammatory agents.