Towards polyketide libraries - II: Synthesis of chiral aracemic DI- and triketides on a solid support

Article abstract of DOI:10.1016/S0040-4039(98)00924-1

A new fluoride ion cleavable linker serves as starter unit for iterative asymmetric aldol reactions on a solid support. The synthetic protocol relies on the boron enolate chemistry of D. A. Evans and a cyclic reestablishment of key functionalities. It entails the opportunity for the generation of di- and triketide libraries.