Synthesis of 1-O-[(3S,4R)-3-hydroxytetrahydrofuran-4-yl]-α-D- glucopyranoside 3,4,3'-triphosphate as a novel potent IP3 receptor ligand

DOI: 10.1016/S0040-4039(98)00954-X

Source and publish data:

Tetrahedron Letters p. 5065 - 5068 (1998)

Update date:2022-08-02

Topics:

Authors:

Tatani, Kazuya

Shuto, Satoshi

Ueno, Yoshihito

Matsuda, Akira

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Article abstract of DOI:10.1016/S0040-4039(98)00954-X

1-O-[(3S,4R)-3-Hydroxytetrahydrofuran-4-yl]-α-D-glucopyranoside 3,4,3'- triphosphate (5) was designed and synthesized as a novel IP₃ receptor ligand. This compound bound strongly to IP₃ receptor from porcine cerebella with an affinity comparable to that of IP₃.

Full text of DOI:10.1016/S0040-4039(98)00954-X

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