Synthesis and preliminary evaluation of (S)-2-(4'-carboxycubyl)glycine, a new selective mGluR1 antagonist

DOI: 10.1016/S0960-894X(98)00265-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1569 - 1574 (1998)

Update date:2022-08-03

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Authors:

Pellicciari, Roberto

Costantino, Gabriele

Giovagnoni, Emiliano

Mattoli, Luisa

Brabet, Isabelle

Pin, Jean-Philippe

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Article abstract of DOI:10.1016/S0960-894X(98)00265-0

The synthesis and the pharmacological evaluation at metabotropic glutamate receptors of S-2-(4'-carboxy-cubyl)glycine (ACUDA, 9) are described. S-2-(4'-Carboxy-cubyl)glycine is a structurally novel group I selective antagonist for mGluR1 subtype.

Full text of DOI:10.1016/S0960-894X(98)00265-0

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