Synthesis of enantiomerically pure carbocyclic α-L-isomeric homonucleosides

Article abstract of DOI:10.1016/S0040-4020(98)00471-2

Synthesis of hitherto unknown carbocyclic α-L-isomeric homonucleosides (8a-b, 9a-b) is described. The key intermediate 6 was synthesized from the known compound 1 as a chiral starting material. Construction of the heterocyclic moiety around the amino group of 6 afforded carbocyclic α-L- isomeric 2',3'-dideoxyhomonucleosides 8a-b and their 2',3'-didehydro-2',3'- dideoxy derivatives 9a-b.