Welcome to LookChem.com Sign In|Join Free

Article Doi

Synthesis, hybridization, and nuclease resistance properties of 2'-O- aminooxyethyl (2'-O-AOE) modified oligonucleotides

DOI: 10.1016/S0040-4039(98)02498-8

Source and publish data:

Tetrahedron Letters p. 661 - 664 (1999)

Update date:2022-07-29

Topics:

Authors:

Kawasaki, Andrew M.Kawasaki, Andrew M.

Casper, Martin D.Casper, Martin D.

Prakash, Thazha P.Prakash, Thazha P.

Manalili, SheriManalili, Sheri

Sasmor, HenriSasmor, Henri

Manoharan, MuthiahManoharan, Muthiah

Cook, P. DanCook, P. Dan

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(98)02498-8

The novel RNA mimic 2'-O-AOE has been incorporated into antisense oligonucleotides. This 2'-O-modification significantly enhances hybridization against target RNA, and furthermore, exhibits specificity for RNA over DNA. The nuclease resistance (SVPD) of 2'-O-AOE modified phosphodiester oligonucleotides is significantly higher than the unmodified DNA and comparable to the 2'-O-MOE oligonucleotides.

View More

Full text of DOI:10.1016/S0040-4039(98)02498-8

Products guided by the article

Product name:[(2S,3R,4R,5R)-4-(2,4-Dichloro-benzyloxy)-5-(2,4-dichloro-benzyloxymethyl)-2-methoxy-tetrahydro-furan-3-yloxy]-acetic acid ethyl ester

Cas No:212060-91-8

212060-91-8

R&D Labs maybe for 212060-91-8

Relevant to this article

Hot Product