Tetrahedron Letters p. 661 - 664 (1999)
Update date:2022-07-29
Topics:
Kawasaki, Andrew M.
Casper, Martin D.
Prakash, Thazha P.
Manalili, Sheri
Sasmor, Henri
Manoharan, Muthiah
Cook, P. Dan
The novel RNA mimic 2'-O-AOE has been incorporated into antisense oligonucleotides. This 2'-O-modification significantly enhances hybridization against target RNA, and furthermore, exhibits specificity for RNA over DNA. The nuclease resistance (SVPD) of 2'-O-AOE modified phosphodiester oligonucleotides is significantly higher than the unmodified DNA and comparable to the 2'-O-MOE oligonucleotides.
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