European Journal of Medicinal Chemistry p. 381 - 387 (1999)
Update date:2022-08-04
Topics:
Sui, Zhihua
Nguyen, Van N.
Altom, Jason
Fernandez, Jeffrey
Hilliard, Jamese J.
Bernstein, Jeffrey I.
Barrett, John F.
Ohemeng, Kwasi A
A series of aza-flavones (3-hydroxy-2-phenyl-4-quinolones) were designed and synthesized as inhibitors of bacterial DNA-gyrase and mammalian topoisomerase II. Structure activity relationships of the compounds against each of the enzymes are discussed.
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