Synthesis and antiviral activity of apio dideoxy nucleosides with azido or amino substituent

Article abstract of DOI:10.1080/07328319808003481

Novel apio dideoxynucleosides with azido or amino substituent were synthesized starting from 1,3-dihydroxyacetone utilizing an acid-catalyzed 1,4conjugated addition as a key step and evaluated for antiviral activity. Unfortunately, they were found to be neither active against HIV-1, HSV-1,2 and poliovirus nor toxic.

Full text of DOI:10.1080/07328319808003481

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Nucleosides and Nucleotides
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Synthesis and Antiviral Activity of Apio
Dideoxy Nucleosides with Azido or
Amino Substituent
Lak Shin Jeong a , Young A Lee a , Hyung Ryong Moon a & Moon Woo
Chun b
a Laboratory of Medicinal Chemistry, College of Pharmacy , Ewha
Womans University , Seoul, 120–750, Korea
b College of Pharmacy , Seoul National University , Seoul, 151–742,
Korea
Published online: 21 Aug 2006.
To cite this article: Lak Shin Jeong , Young A Lee , Hyung Ryong Moon & Moon Woo Chun (1998)
Synthesis and Antiviral Activity of Apio Dideoxy Nucleosides with Azido or Amino Substituent,
Nucleosides and Nucleotides, 17:8, 1473-1487, DOI: 10.1080/07328319808003481
To link to this article: http://dx.doi.org/10.1080/07328319808003481
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