Bioorganic and Medicinal Chemistry Letters p. 1767 - 1770 (1998)
Update date:2022-07-30
Topics:
Mogensen, John P.
Roberts, Stanley M.
Bowler, Andrew N.
Thomsen, Christian
Knutsen, Lars J. S.
The synthesis and purinergic receptor binding of novel adenosine A3 ligands is described. Many selective A3 receptor agonists e.g. N-(3- iodobenzyl)adenosine-5'-methyluronamide (IB-MECA) contain a 4'- ribosylalkylamide moiety. We found that this amide and other 4'-functional groups could be replaced with an isosteric isoxazole, and the target molecules retained potent binding to the recombinant human A3 receptor.
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Doi:10.1016/S0968-0896(03)00401-2
(2003)Doi:10.1021/om980151z
(1998)Doi:10.3987/COM-05-S(T)74
(2006)Doi:10.1016/S0040-4039(97)00410-3
(1997)Doi:10.1016/S0957-4166(98)00282-1
(1998)Doi:10.1016/S0040-4020(98)83036-6
(1998)
