Synthesis of pyrrolobenzodiazepines via the PIFA oxidation of amines. Synthesis of 8-deoxy DC-81

DOI: 10.1016/S0040-4020(98)83036-6

Source and publish data:

Tetrahedron p. 11749 - 11754 (1998)

Update date:2022-07-30

Topics:

Authors:

Kraus, George A.

Melekhov, Alex

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4020(98)83036-6

PIFA can be used to introduce the imine moiety into a precursor to the pyrrolobenzodiazepines in 62% yield. This oxidation completes an efficient four-step synthesis of 8-deoxy DC-81.

Full text of DOI:10.1016/S0040-4020(98)83036-6

Products guided by the article

Product name:N-(5-methoxy-2-nitrobenzoyl)pyrrolidin-2-methanol

Cas No:214416-11-2

R&D Labs maybe for 214416-11-2

Hebei Maison Chemical Co.,Ltd

website:http://www.maisonchem.com.cn

Contact:0086-311-83833777

Address:Leitou industrial district, xinji, shijiazhuang city, hebei province,
JIAXING SUNS INTERNATIONAL TRADE CO LTD

Contact:18367306858

Address:No.123,Huixin Avenue,Huimin Dist
Yantai Derun Liquid Crystal Materials Co. Ltd.

website:http://www.ytderun.com

Contact:86-535-6300169

Address:ROOM 90, XIANGFU STREET, FUSHAN NEW-HIGH-TECH IDUSTRY ZONE, YANTAI
NEW FORTUNE INDUSTRIAL CO.,LTD.

website:http://newfortune.lookchem.com/

Contact:+86-25-8645-9456

Address:C4-105 GREEN ISLAND FLOWER TOWN
HuiFeiChem PharmaTech Co.Ltd

Contact:0510-85393305

Address:1619 Huishan Avenue, Huishan District, Wuxi,

Relevant to this article

Nickel-Catalyzed Transformation of Diazoacetates to Alkyl Radicals Using Alcohol as a Hydrogen Source

Doi:10.1021/acs.orglett.9b03610
(2019)
Novel pyrene- and anthracene-based Schiff base derivatives as Cu ²⁺ and Fe³⁺ fluorescence turn-on sensors and for aggregation induced emissions

Doi:10.1039/c2ta00574c
(2013)
Heteropolymetallic compounds containing 1,1′-bis(diphenylphosphino)ferrocene (DPPF) and pyrazolate ligands: Synthesis, spectroscopic characterization and reactivity. Crystal and molecular structure of [(DPPF)Pt(az)₂] [azH = pyrazole (pzH) or 3,5-dimethylpyrazole] and [(DPPF)Pt(μ-pz)₂CdI₂]

Doi:10.1039/a805432k
(1998)
A noncatalytic approach to hetaryl-annulated 1,2,4-thiadiazine-1,1-dioxides

Doi:10.1002/jhet.1029
(2013)
Carvone based approaches to chiral functionalised B-seco-taxanes

Doi:10.1039/a805862h
(1998)
Effect of the Orientation of an α-Substituent on Vicinal 13C-1H Spin-Spin Coupling Constants

Doi:10.1002/mrc.1260280113
(1990)

Article Doi