Synthesis of pyrrolobenzodiazepines via the PIFA oxidation of amines. Synthesis of 8-deoxy DC-81

DOI: 10.1016/S0040-4020(98)83036-6

Source and publish data:

Tetrahedron p. 11749 - 11754 (1998)

Update date:2022-07-30

Topics:

Authors:

Kraus, George A.

Melekhov, Alex

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Article abstract of DOI:10.1016/S0040-4020(98)83036-6

PIFA can be used to introduce the imine moiety into a precursor to the pyrrolobenzodiazepines in 62% yield. This oxidation completes an efficient four-step synthesis of 8-deoxy DC-81.

Full text of DOI:10.1016/S0040-4020(98)83036-6

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Product name:N-(5-methoxy-2-nitrobenzoyl)pyrrolidin-2-methanol

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