Synthesis of pyrrolobenzodiazepines via the PIFA oxidation of amines. Synthesis of 8-deoxy DC-81

DOI: 10.1016/S0040-4020(98)83036-6

Source and publish data:

Tetrahedron p. 11749 - 11754 (1998)

Update date:2022-07-30

Topics:

Authors:

Kraus, George A.

Melekhov, Alex

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4020(98)83036-6

PIFA can be used to introduce the imine moiety into a precursor to the pyrrolobenzodiazepines in 62% yield. This oxidation completes an efficient four-step synthesis of 8-deoxy DC-81.

Full text of DOI:10.1016/S0040-4020(98)83036-6

Products guided by the article

Product name:N-(5-methoxy-2-nitrobenzoyl)pyrrolidin-2-methanol

Cas No:214416-11-2

R&D Labs maybe for 214416-11-2

Shandong General Materials Co.,Ltd（Shandong Aoertong Chemical Co., Ltd）

Contact:86-531-88072280

Address:No. 1825 Hualong Road, Licheng District, Jinan, Shandong, China
Taiwan Surfactant Corp.

Contact:886 2 2541 0022

Address:8 Fl., No. 11, Sec. 1, Chung Shan North Rd., Taipei, Taiwan R.O.C.
Tomo Pharma Chem Co., Limited

Contact:+86-158-05817090

Address:ROOM 9F, FLAT 2, GUODU DEVELOPING BLDG, No.182, ZHAOHUI ROAD
Guangzhou Puho Pharmaceutical Technology Co. Ltd.

Contact:86-20-29848035/29848075

Address:No.166, Chaoyang East Road, Panyu District, Guangzhou City, Guangdong Province
Shanghai Forever Synthesis Co.,Ltd.

Contact:021-61124658

Address:Zhoukang Road,Pudong New District,Shanghai,China

Relevant to this article

Nickel-Catalyzed Transformation of Diazoacetates to Alkyl Radicals Using Alcohol as a Hydrogen Source

Doi:10.1021/acs.orglett.9b03610
(2019)
Novel pyrene- and anthracene-based Schiff base derivatives as Cu ²⁺ and Fe³⁺ fluorescence turn-on sensors and for aggregation induced emissions

Doi:10.1039/c2ta00574c
(2013)
Heteropolymetallic compounds containing 1,1′-bis(diphenylphosphino)ferrocene (DPPF) and pyrazolate ligands: Synthesis, spectroscopic characterization and reactivity. Crystal and molecular structure of [(DPPF)Pt(az)₂] [azH = pyrazole (pzH) or 3,5-dimethylpyrazole] and [(DPPF)Pt(μ-pz)₂CdI₂]

Doi:10.1039/a805432k
(1998)
A noncatalytic approach to hetaryl-annulated 1,2,4-thiadiazine-1,1-dioxides

Doi:10.1002/jhet.1029
(2013)
Carvone based approaches to chiral functionalised B-seco-taxanes

Doi:10.1039/a805862h
(1998)
Effect of the Orientation of an α-Substituent on Vicinal 13C-1H Spin-Spin Coupling Constants

Doi:10.1002/mrc.1260280113
(1990)

Article Doi