Concise enantioselective synthesis of (+)-aspicilin based on a ruthenium catalyzed olefin metathesis reaction

Article abstract of DOI:10.1016/S0040-4039(98)01130-7

An efficient enantioselective synthesis of (+)-aspicilin has been achieved in 12 steps from (2E,5E)-1,7-dibenzyloxy-2,5-heptadiene-4-ol employing Red-Al-promoted reductive cleavage of the benzyl 4-hydroxy-2- butenyl ether structure and ruthenium catalyzed