A new convenient synthesis of 1-(3-hydroxy-4-methoxyphenyl)ethane-1,2- diol (iso-MHPG) and its enantiomers

Article abstract of DOI:10.1080/00397919808004875

A safe and efficient process has been developed for the multigram synthesis of 1-(3-hydroxy-4-methoxyphenyl)ethane-1,2-diol (iso-MHPG) 2, via osmium-catalysed dihydroxylation of 3-benzyloxy-4-methoxystyrene 5, and subsequent debenzylation. The methodology

Full text of DOI:10.1080/00397919808004875

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Synthetic Communications:
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Synthetic Organic Chemistry
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A New Convenient Synthesis
of 1-(3-Hydroxy-4-
Methoxyphenyl)Ethane-1,2-
Diol (iso-Mhpg) and its
Enantiomers
Adrian J. Fisher a & Frank Kerrigan a
a Knoll Pharmaceuticals, Research &
Development Department , Pennyfoot St,
Nottingham, NG1 1GF, UK
Published online: 23 Aug 2006.
To cite this article: Adrian J. Fisher & Frank Kerrigan (1998) A New Convenient
Synthesis of 1-(3-Hydroxy-4-Methoxyphenyl)Ethane-1,2-Diol (iso-Mhpg) and
its Enantiomers, Synthetic Communications: An International Journal for
Rapid Communication of Synthetic Organic Chemistry, 28:16, 2959-2968, DOI:
10.1080/00397919808004875
To link to this article: http://dx.doi.org/10.1080/00397919808004875
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