A new route to the asymmetric synthesis of (-)-malyngolide and (-)-epi- malyngolide using N-sulfonyl-l,3-oxazolidines as chiral auxiliaries

Article abstract of DOI:10.1016/S0040-4020(98)00488-8

(-)-Malyngolide (1), an antibiotically active δ-lactone, and its epimer 10 were prepared enantioselectively using [2R,2(1S),4R]- and [2R,2(1R),4R]- 4-ethyl-3-(2-nitrobenzenesulfonyl)-2-(1-nonyl-2-oxocyclopentyl)-1,3- oxazolidine (5a and 5b) as key-interme