
Tetrahedron Letters p. 7173 - 7176 (1998)
Update date:2022-08-05
Topics:
Lindstroem, Ulf M.
Somfai, Peter
An asymmetric synthesis of (+)-1-deoxynojirimycin (1) in 14 steps starting from diene (5) is described. The key transformations in the sequence are a sharpless dihydroxylation and epoxidation followed by a regio- and stereoselective aminolysis of vinyl epoxide 11 to give piperidine 12.
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