Synthetic studies of halichondrin B, an antitumor polyether macrolide isolated from a marine sponge. 8. Synthesis of the lactone part (C1-C36) via Horner-Emmons coupling between C1-C15 and C16-C36 fragments and Yamaguchi lactonization.

DOI: 10.1016/S0040-4039(97)10364-1

Source and publish data:

Tetrahedron Letters p. 8965 - 8968 (1997)

Update date:2022-09-26

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Authors:

Horita, Kiyoshi

Nagasawa, Masaaki

Hachiya, Shun-Ichiro

Sakurai, Youji

Yamazaki, Tatsuya

Uenishi, Jun'ichi

Yonemitsu, Osamu

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Article abstract of DOI:10.1016/S0040-4039(97)10364-1

The lactone part (2) of halichondrin B (1) was synthesized by Yamaguchi macrolactonization of the seco-acid (3), which was synthesized via coupling of C1-C15 (4) with C16-C36 (5). prepared through stereoselective construction of the E ring starting from C16-C26 (7) and C27-C36 (8).

Full text of DOI:10.1016/S0040-4039(97)10364-1

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