Synthetic studies of halichondrin B, an antitumor polyether macrolide isolated from a marine sponge. 8. Synthesis of the lactone part (C1-C36) via Horner-Emmons coupling between C1-C15 and C16-C36 fragments and Yamaguchi lactonization.

DOI: 10.1016/S0040-4039(97)10364-1

Source and publish data:

Tetrahedron Letters p. 8965 - 8968 (1997)

Update date:2022-09-26

Topics:

Authors:

Horita, Kiyoshi

Nagasawa, Masaaki

Hachiya, Shun-Ichiro

Sakurai, Youji

Yamazaki, Tatsuya

Uenishi, Jun'ichi

Yonemitsu, Osamu

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(97)10364-1

The lactone part (2) of halichondrin B (1) was synthesized by Yamaguchi macrolactonization of the seco-acid (3), which was synthesized via coupling of C1-C15 (4) with C16-C36 (5). prepared through stereoselective construction of the E ring starting from C16-C26 (7) and C27-C36 (8).

Full text of DOI:10.1016/S0040-4039(97)10364-1

Products guided by the article

Product name:C₄₆H₆₆O₁₂Si

Cas No:214533-36-5

R&D Labs maybe for 214533-36-5

Shanghai Hohance Chemical Co., ltd

Contact:13914753421

Address:Fl.5；Bld. 70, Lane 1500; Xinfei Road
Wuxi Olite Chemical Co., Ltd.

Contact:86-510-82853889

Address:Rm.3732, No.18-2,Yonghe Rd.,Wuxi,Jiangsu,214023,China
Nanjing Chemical Material Corp.(NCMC)

website:http://www.njchemm.com

Contact:0086-25-83172879

Address:B12 Technology and Innovation Building, Nanjing Tech University, No.5 New Model Road
Beyond Pharmaceutical Co., Ltd

Contact:+86-571-8195-3185

Address:No. 13-1, Liansheng Road, Yuhang District
Kraeber & Co GmbH

Contact:+49-4101-3053-0

Address:Waldhofstrasse 14 ,25474 Ellerbek Germany

Relevant to this article

β-1,4-Galactosyltransferase-catalyzed synthesis of the branched tetrasaccharide repeating unit of Streptococcus pneumoniae Type 14

Doi:10.1016/S0968-0896(98)00095-9
(1998)
New 1,3,5-triazine derivatives as templates for the homogeneous phase synthesis of chemical libraries

Doi:10.1016/S0040-4039(98)01654-2
(1998)
Sequential C-H and C-Ru bond formation and cleavage during the thermally induced rearrangement of aryl ruthenium(II) complexes with [C₆H₃(CH₂NMe₂)₂-2,6] ^- as a bidentate η²-C,N coordinated ligand. the crystal structures of the isomeric pairs [RuCl{η⁶-C₁₀H₁₄}

Doi:10.1021/om980343u
(1998)
Asymmetric Induction via a Helically Chiral Anion: Enantioselective Pentacarboxycyclopentadiene Br?nsted Acid-Catalyzed Inverse-Electron-Demand Diels-Alder Cycloaddition of Oxocarbenium Ions

Doi:10.1021/jacs.8b00260
(2018)
Doi:10.1002/ardp.19542870922
(1954)
PREPARATION, STRUCTURE AND ASYMMETRIC DIELS-ALDER REACTIONS OF 10-ARYLSULFONYLISOBORNYL ACRYLATES

Doi:10.1016/S0040-4039(01)81712-3
(1984)

Article Doi