Unified approach towards medium ring allylic ethers. Stereoselective synthesis of 2,10-dialkylated (E)-oxacyclodec-3-enes by palladium catalyzed cyclization

Article abstract of DOI:10.1016/S0040-4039(98)01506-8

Δ³-Unsaturated 10-membered ring ethers (5,6,7,8,9, 10-hexahydro-2H- oxecins) 11a and 11b have been prepared by intramolecular Pd-catalyzed allylic alkylation. The ethers are formed with E-configurated olefinic double bond and with the chiral ce