Design and synthesis of analogs of vitamin E: Antiproliferative activity against human breast adenocarcinoma cells

Article abstract of DOI:10.1016/S0960-894X(98)00438-7

Analogs of α-tocopherol (vitamin E; compounds 3-9) have been synthesized and tested for their antiproliferative activity using the human breast cancer cell line, MCF7. Compounds 6-9 were synthesized from a common synthon, rac-Trolox (14) and are soluble/m