Bioorganic and Medicinal Chemistry Letters p. 2443 - 2446 (1998)
Update date:2022-08-04
Topics:
Li, Zhengong
Yeo, Su Ling
Pallen, Catherine J.
Ganesan
A library of 108 α,α-difluoromethylenephosphonic acids was prepared by Ugi four-component condensation using Rink-NH2 resin, 4- [(diethoxyphosphinyl)difluoromethyl]benzoic acid, and a set of 18 aldehydes and 6 isonitriles. Following resin cleavage, the diethylphosphonate esters were hydrolyzed with trimethylsilyl bromide to yield the free acids which were assayed for inhibition of PTPα, PTPβ and PTPε.
View MoreContact:+86-511-88790000
Address:338 North Yushan Rd, Zhenjiang, Jiangsu 212016
website:http://www.ringchemicals.com/
Contact:+1-416-493-6870
Address:Toronto, Canada
Dongguan Albiya Energy Science and Technology Co.,Ltd
Contact:+86-769-22181286
Address:Huanan Industial Park, Dongguan,China
ShanDong XinDa Chemical CO.,LTD(expird)
Contact:086-0311-87580543
Address:No.168, High Technology Development Zone Jinan Shandong China
Contact:+86-571-86025531 / 86024803
Address:1218-24 Guangyin Mansion,42 Fengqi East Road
Doi:10.1002/ejoc.201201454
(2013)Doi:10.1021/acs.orglett.6b03789
(2017)Doi:10.1007/BF00863074
(1992)Doi:10.1039/c3ob40431e
(2013)Doi:10.1016/j.ica.2013.03.018
(2013)Doi:10.1007/s00044-013-0651-z
(2014)
