Synthesis of 1-amino-2,2-dialkylcyclopropanecarboxylic acids via base-induced cyclization of γ-chloro-α-imino ester

Article abstract of DOI:10.1021/jo00102a022

β-Chloro ketones were oxidatively transformed into α-keto carboxylic esters and condensed with primary amines in the presence of titanium(IV) chloride. Base-induced cyclization of the resulting γ-chloro-α-imino esters, incorporating suitable N-substituent