Synthesis and biological evaluation of a new class of vaccine adjuvants: Aminoalkyl glucosaminide 4-phosphates (AGPs)

DOI: 10.1016/S0960-894X(99)00374-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2273 - 2278 (1999)

Update date:2022-07-30

Topics:

Authors:

Johnson, David A.

Sowell, C. Gregory

Johnson, Craig L.

Livesay, Mark T.

Keegan, David S.

Rhodes, Michael J.

Ulrich, J. Terry

Ward, Jon R.

Cantrell, John L.

Brookshire, Valerie G.

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Article abstract of DOI:10.1016/S0960-894X(99)00374-1

A novel series of acylated ω-aminoalkyl 2-amino-2-deoxy-4-phosphono-β- D-glucopyranosides (aminoalkyl glucosaminide 4-phosphates) was synthesized and screened for immunostimulant activity. Several of these compounds enhance the production of tetanus toxoid-specific antibodies in mice and augment vaccine-induced cytotoxic T cells against EG.7-ova target cells.

Full text of DOI:10.1016/S0960-894X(99)00374-1

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