Synthesis and biological evaluation of a new class of vaccine adjuvants: Aminoalkyl glucosaminide 4-phosphates (AGPs)

Article abstract of DOI:10.1016/S0960-894X(99)00374-1

A novel series of acylated ω-aminoalkyl 2-amino-2-deoxy-4-phosphono-β- D-glucopyranosides (aminoalkyl glucosaminide 4-phosphates) was synthesized and screened for immunostimulant activity. Several of these compounds enhance the production of tetanus toxoid-specific antibodies in mice and augment vaccine-induced cytotoxic T cells against EG.7-ova target cells.