Bioorganic and Medicinal Chemistry Letters p. 2273 - 2278 (1999)
Update date:2022-07-30
Topics:
Johnson, David A.
Sowell, C. Gregory
Johnson, Craig L.
Livesay, Mark T.
Keegan, David S.
Rhodes, Michael J.
Ulrich, J. Terry
Ward, Jon R.
Cantrell, John L.
Brookshire, Valerie G.
A novel series of acylated ω-aminoalkyl 2-amino-2-deoxy-4-phosphono-β- D-glucopyranosides (aminoalkyl glucosaminide 4-phosphates) was synthesized and screened for immunostimulant activity. Several of these compounds enhance the production of tetanus toxoid-specific antibodies in mice and augment vaccine-induced cytotoxic T cells against EG.7-ova target cells.
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