
Tetrahedron Letters p. 7823 - 7826 (1998)
Update date:2022-07-30
Topics: Protecting groups Retrosynthetic analysis Purification and characterization Functional Group Transformations Optimization and Yield Improvement
Birkbeck, Anthony A.
Enders, Dieter
The marine natural product (+)-pectinatone containing 'skip' 1,3- dimethyl stereocentres was synthesised via the iterative alkylation of propanal SAMP-hydrazone with β-branched iodides. Factors affecting the selectivity of the alkylation reaction and the in situ formation of volatile β-branched iodides are described.
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