The total synthesis of (+)-pectinatone: An iterative alkylation approach based on the SAMP-hydrazone method

DOI: 10.1016/S0040-4039(98)01742-0

Source and publish data:

Tetrahedron Letters p. 7823 - 7826 (1998)

Update date:2022-07-30

Topics: Protecting groups Retrosynthetic analysis Purification and characterization Functional Group Transformations Optimization and Yield Improvement

Authors:

Birkbeck, Anthony A.

Enders, Dieter

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Article abstract of DOI:10.1016/S0040-4039(98)01742-0

The marine natural product (+)-pectinatone containing 'skip' 1,3- dimethyl stereocentres was synthesised via the iterative alkylation of propanal SAMP-hydrazone with β-branched iodides. Factors affecting the selectivity of the alkylation reaction and the in situ formation of volatile β-branched iodides are described.

Full text of DOI:10.1016/S0040-4039(98)01742-0

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