Synthesis and mild conversion of 1,5-benzodiazepine iminothioethers into hydrazides

Article abstract of DOI:10.1007/BF02290727

4-Methylthio-2,3-dihydro-1H-1,5-benzodiazepine derivatives were prepared by alkylation of tetrahydro-1H-1,5-benzodiazepine-2-thiones with iodomethane or dimethyl sulfate in the presence of base or using phase-transfer catalysis. The desired 4-acyl-hydrazino-2,3-dihydro-1H-1,5-benzodiazepines resulted from the reaction of iminothioethers with hydrazides. 1998 Plenum Publishing Corporation.