A highly stereocontrolled asymmetric synthesis of the Taxol C-13 side chain; (4S, 5R)-2,4-Diphenyloxazoline-5 carboxylic acid

DOI: 10.1016/S0040-4039(98)01804-8

Source and publish data:

Tetrahedron Letters p. 8129 - 8132 (1998)

Update date:2022-09-26

Topics:

Authors:

Lee, Kee-Young

Kim, Yong-Hyun

Park, Min-Sung

Ham, Won-Hun

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Article abstract of DOI:10.1016/S0040-4039(98)01804-8

A stereoselective synthesis of (4S, 5R)-2,4-diphenyloxaline-5-carboxylic acid, a precursor of the Taxol C-13 side chain was achieved using palladium- catalyzed oxazoline formation reaction from commercially available amino acid.

Full text of DOI:10.1016/S0040-4039(98)01804-8

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