Bioorganic and Medicinal Chemistry Letters p. 907 - 912 (1999)
Update date:2022-08-04
Topics:
Hu, Lain-Yen
Ryder, Todd R.
Rafferty, Michael F.
Cody, Wayne L.
Lotarski, Susan M.
Miljanich, George P.
Millerman, Elizabeth
Rock, David M.
Song, Yuntao
Stoehr, Sally J.
Taylor, Charles P.
Weber, Mark L.
Szoke, Balazs G.
Vartanian, Mark G.
Selective N-type voltage sensitive calcium channel (VSCC) blockers have shown utility in several models of stroke and pain. We are especially interested in small molecule N-type calcium channel blockers for therapeutic use. Herein, we report a series of N,N-dialkyl-dipeptidylamines with potent functional activity at N-type VSCCs and in vivo efficacy. The synthesis, SAR, and pharmacological evaluation of this series are discussed.
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