Bioorganic and Medicinal Chemistry Letters p. 907 - 912 (1999)
Update date:2022-08-04
Topics:
Hu, Lain-Yen
Ryder, Todd R.
Rafferty, Michael F.
Cody, Wayne L.
Lotarski, Susan M.
Miljanich, George P.
Millerman, Elizabeth
Rock, David M.
Song, Yuntao
Stoehr, Sally J.
Taylor, Charles P.
Weber, Mark L.
Szoke, Balazs G.
Vartanian, Mark G.
Selective N-type voltage sensitive calcium channel (VSCC) blockers have shown utility in several models of stroke and pain. We are especially interested in small molecule N-type calcium channel blockers for therapeutic use. Herein, we report a series of N,N-dialkyl-dipeptidylamines with potent functional activity at N-type VSCCs and in vivo efficacy. The synthesis, SAR, and pharmacological evaluation of this series are discussed.
View MoreChengdu Cogon Bio-tech Co., Ltd.
Contact:86-28-85171192
Address:NO.52.YongFeng Rd. Chengdu,610041,P.R.China.
Contact:+86-579-85206992
Address:No 451 chouzhou north road ,room 1106 int'l business center , yiwu ,china
Hangzhou innopharma technology Co,.Ltd.(expird)
Contact:+86-13388601988
Address:Room845,lixin building, moganshan road, hangzhou, china
Xuzhou Tianrun Chemical Co.,Ltd
website:http://www.tianrunchem.cn
Contact:86-516-83832636
Address:fuxing road
Contact:+86-515-88356562
Address:No.2, West Daqing Road, Yancheng, Jiangsu, China
Doi:10.24820/ARK.5550190.P011.226
(2020)Doi:10.1016/S0957-4166(98)00119-0
(1998)Doi:10.1039/c5ob02092a
(2015)Doi:10.1039/a802098a
(1998)Doi:10.1039/b101111l
(2001)Doi:10.1002/(SICI)1521-4184(199805)331:5<163::AID-ARDP163>3.0.CO;2-3
(1998)
