Bioorganic and Medicinal Chemistry Letters p. 4761 - 4769 (2005)
Update date:2022-08-05
Topics:
Betageri, Raj
Zhang, Yan
Zindell, Renee M.
Kuzmich, Daniel
Kirrane, Thomas M.
Bentzien, Joerg
Cardozo, Mario
Capolino, Alison J.
Fadra, Tazmeen N.
Nelson, Richard M.
Paw, Zofia
Shih, Daw-Tsun
Shih, Cheng-Kon
Zuvela-Jelaska, Ljiljana
Nabozny, Gerald
Thomson, David S.
Compound 1, a potent glucocorticoid receptor ligand, contains a quaternary carbon bearing trifluoromethyl and hydroxyl groups. This paper describes the effect of replacing the trifluoromethyl group on binding and agonist activity of the GR ligand 1. The r
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