Stereoselective synthesis of an isomer of membrenone-C via an aldol based two directional chain extension

Article abstract of DOI:10.1016/S0040-4039(98)01846-2

An isomer of Membrenone-C was prepared in 8 steps (17% yield) with 93% overall ds starting from the ethyl ketone (S)-10. Key steps are the boron- mediated aldol followed by anti selective reduction, giving the C₆-C₁₀ stereochemistry,