Bioorganic and Medicinal Chemistry Letters p. 2855 - 2858 (1998)
Update date:2022-08-02
Topics:
Poncet, Joel
Hortala, Laurent
Busquet, Magali
Gueritte-Voegelein, Francoise
Thoret, Sylvie
Pierre, Alain
Atassi, Ghanem
Jouin, Patrick
A cyclic analog of the natural antiproliferative compound dolastatin 10 was synthesized by introducing an ester link between the N- and C-terminal residues which were modified accordingly. The final macrolactonization was performed by using isopropenyl chloroformate and DMAP as reagents. This analog exhibits submicromolar antiproliferative activity against the L1210 and HT29 cell lines and inhibits in vitro tubulin polymerization (IC50, 39 μM).
View Morewebsite:http://www.shtopchem.com/
Contact:0086-0576-87776998
Address:room no 1608,xuhui business building yude road,xujiahui street, xuhui district
Anhui Asahikasei Chemical Co., Ltd
Contact:86-551-4259770
Address:No. 88 Linquan Road Hefei Anhui China
ShangHai Original Economy-Trade Develop Co.,Ltd.,
Contact:86-21-68552131
Address:shanghai
Contact:+86-731-84427351
Address:154 JIANXIANG SOUTH ROAD
Contact:+86-518-81061113
Address:No. 8 Lingzhou Road, Lianyungang, Jiangsu, China
Doi:10.1021/ja01021a048
(1968)Doi:10.1002/hc.21107
(2013)Doi:10.1021/ja00881a026
(1962)Doi:10.1021/om980667i
(1998)Doi:10.14233/ajchem.2015.18417
(2015)Doi:10.1016/0040-4020(69)85017-9
(1969)