β-analogs of PLG (L-prolyl-L-leucyl-glycinamide): Ex-chiral pool syntheses and dopamine D2 receptor modulating effects

Article abstract of DOI:10.1016/S0960-894X(98)00507-1

Starting from (S)- and (R)-aspartic acid enantiomerically pure β- proline derivatives were synthesized. These chiral building blocks were transformed into β-analogs of the dopamine receptor modulating peptide PLG. According to dopamine receptor binding st