Synthesis and biological evaluation of fully synthetic bryostatin analogues

DOI: 10.1016/S0040-4039(98)01955-8

Source and publish data:

Tetrahedron Letters p. 8625 - 8628 (1998)

Update date:2022-07-30

Topics:

Authors:

Wender, Paul A.

De Brabander, Jef

Harran, Patrick G.

Hinkle, Kevin W.

Lippa, Blaise

Pettit, George R.

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Article abstract of DOI:10.1016/S0040-4039(98)01955-8

The first members of a new class of designed bryostatin analogues are synthesized using a novel, convergent macrotransacetalization strategy. These simplified analogues, lacking the A-ring of bryostatin 1 and possessing a simplified B-ring, exhibit signif

Full text of DOI:10.1016/S0040-4039(98)01955-8

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Product name:Octanoic acid (E)-(1S,5S,9S,11S,15R,19R,21S,24S)-19-((R)-1-benzyloxy-ethyl)-11-tert-butyl-1,15-dihydroxy-23-[1-methoxycarbonyl-meth-(E)-ylidene]-2,2-dimethyl-17-oxo-6,12,18,25,26-pentaoxa-tricyclo[19.3.1.1^5,9]hexacos-3-en-24-yl ester

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